ICLM Journal Club
This Week - 10 February 2017 (9:30 a.m., Gonda 2nd Floor Conference Room)
Speaker: Tristan Shuman
Title: Breakdown of spatial coding and synchronization in epilepsy
Epilepsy causes dramatic cell death and reorganization of interneuron circuits in both humans and rodent models but the consequences of these changes on the hippocampal network remain unknown. Using in vivo electrophysiology in head-fixed mice running in virtual reality, I have found dramatic alterations of hippocampal processing in chronically epileptic mice. Epileptic mice had reduced local field potential amplitude and coherence, altered cross-frequency coupling, and altered phase preferences to ongoing theta oscillations. In addition, using calcium imaging with miniature microscopes, I have found that place fields in epileptic mice contained less spatial information and were highly unstable across days. Together, these findings indicate that desynchronization within the hippocampus contributes to the cognitive dysfunction observed in epilepsy.
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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