Difference between revisions of "ICLM Journal Club"
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<u>Abstract:</u> The cerebellum has a clear role in the coordination of motor movement, as diseases or insults that disrupt cerebellar function result in the loss of motor control. However, over the past 5-10 years multiple independent lines of research strongly suggests the cerebellum plays a much broader role in animal behavior, contributing to aspects of cognition, emotion, and executive function. In the first half of my talk, I will provide an overview of multiple recent rodent studies that link specific cerebellum-to-forebrain circuits to aspects of cognitive behavior, including social cognition and behavioral flexibility. In the second half, I will present recent preliminary experiments from my own laboratory using a new behavioral paradigm (at least to the cerebellar field) to examine the role of the cerebellum in behavioral flexibility. | <u>Abstract:</u> The cerebellum has a clear role in the coordination of motor movement, as diseases or insults that disrupt cerebellar function result in the loss of motor control. However, over the past 5-10 years multiple independent lines of research strongly suggests the cerebellum plays a much broader role in animal behavior, contributing to aspects of cognition, emotion, and executive function. In the first half of my talk, I will provide an overview of multiple recent rodent studies that link specific cerebellum-to-forebrain circuits to aspects of cognitive behavior, including social cognition and behavioral flexibility. In the second half, I will present recent preliminary experiments from my own laboratory using a new behavioral paradigm (at least to the cerebellar field) to examine the role of the cerebellum in behavioral flexibility. | ||
| − | <u>Relevant Paper(s):</u> http://science.sciencemag.org/content/363/6424/eaav0581.full | + | <u>Relevant Paper(s):</u> |
| + | |||
| + | http://science.sciencemag.org/content/363/6424/eaav0581.full | ||
https://elifesciences.org/articles/36401 | https://elifesciences.org/articles/36401 | ||
Revision as of 04:30, 4 April 2019
This Week - 5 April 2019 (9:30 a.m., Gonda 2nd Floor Conference Room)
Speaker: Paul Mathews
Title: Cerebellar contributions to cognitive behavior
Abstract: The cerebellum has a clear role in the coordination of motor movement, as diseases or insults that disrupt cerebellar function result in the loss of motor control. However, over the past 5-10 years multiple independent lines of research strongly suggests the cerebellum plays a much broader role in animal behavior, contributing to aspects of cognition, emotion, and executive function. In the first half of my talk, I will provide an overview of multiple recent rodent studies that link specific cerebellum-to-forebrain circuits to aspects of cognitive behavior, including social cognition and behavioral flexibility. In the second half, I will present recent preliminary experiments from my own laboratory using a new behavioral paradigm (at least to the cerebellar field) to examine the role of the cerebellum in behavioral flexibility.
Relevant Paper(s):
http://science.sciencemag.org/content/363/6424/eaav0581.full
https://elifesciences.org/articles/36401
https://www.nature.com/articles/s41593-017-0004-1
About Us
Introduction
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Organizers:
Current Faculty Advisor:
Past Organizers:
i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)
ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)
iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)
iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)
v) Walt Babiec (O'Dell Lab) (2013-2014)
vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)
vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)
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