Difference between revisions of "ICLM Journal Club"

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(This Week - 11 October 2019 (9:30 a.m., Gonda 2nd Floor Conference Room))
(This Week - 22 May 2020 (9:30 a.m., via ZOOM))
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=<font color="blue">'''This Week - 18 October 2019 (9:30 a.m., Gonda 2<sup>nd</sup> Floor Conference Room)'''</font>=
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=<font color="blue">'''This Week - 29 May 2020 (9:30 a.m., via ZOOM)'''</font>=
  
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<u>Speaker:</u> ''' Peter Schuette '''
  
<u>Title:</u> ''' No Journal club this week due to SfN meeting. See ya next week! '''
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<u>Title:</u> “Long-term characterization of hippocampal remapping during contextual fear acquisition and extinction”
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<u>Abstract:</u> Hippocampal CA1 place cell spatial maps are known to alter their firing properties in response to contextual fear conditioning—a process called ‘remapping.’ In the present study, we use chronic calcium imaging to examine contextual fear-induced remapping over an extended period of time and with thousands of neurons, and we demonstrate that hippocampal ensembles encode space at a finer scale following contextual fear conditioning. This effect is strongest near the shock grid. We also characterize the long- term effects of shock on place cell ensemble stability, demonstrating that shock delivery induces a several day period of high fear and low between-session place field stability, followed by a new, stable spatial representation that appears after behavioral extinction of conditioned fear. Finally, we identify a novel group of CA1 neurons that robustly encode freeze behavior independently from spatial location. Thus, following fear conditioning, hippocampal CA1 place cells sharpen their spatial tuning and dynamically change spatial encoding stability throughout fear learning and extinction.
  
 
='''About Us'''=
 
='''About Us'''=

Revision as of 17:12, 26 May 2020

This Week - 29 May 2020 (9:30 a.m., via ZOOM)

Speaker: Peter Schuette

Title: “Long-term characterization of hippocampal remapping during contextual fear acquisition and extinction”

Abstract: Hippocampal CA1 place cell spatial maps are known to alter their firing properties in response to contextual fear conditioning—a process called ‘remapping.’ In the present study, we use chronic calcium imaging to examine contextual fear-induced remapping over an extended period of time and with thousands of neurons, and we demonstrate that hippocampal ensembles encode space at a finer scale following contextual fear conditioning. This effect is strongest near the shock grid. We also characterize the long- term effects of shock on place cell ensemble stability, demonstrating that shock delivery induces a several day period of high fear and low between-session place field stability, followed by a new, stable spatial representation that appears after behavioral extinction of conditioned fear. Finally, we identify a novel group of CA1 neurons that robustly encode freeze behavior independently from spatial location. Thus, following fear conditioning, hippocampal CA1 place cells sharpen their spatial tuning and dynamically change spatial encoding stability throughout fear learning and extinction.

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Shonali Dhingra

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

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