Difference between revisions of "ICLM Journal Club"

From LMP Journal Club
Jump to: navigation, search
(This Week - 29 April 2022 (9:30 a.m., via Zoom))
(About Us)
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
=<font color="blue">'''This Week - 06 May 2022 (9:30 a.m., via Zoom)'''</font>=
+
=<font color="blue">'''This Week - 10 June 2022 (9:30 a.m., via Zoom)'''</font>=
  
<u>Speaker:</u> ''Ana Sias''
+
<u>Speaker:</u> ''Caitlin Goodpaster''
  
<u>Title: </u> ''' “ Dopamine projections to the basolateral amygdala mediate the encoding of outcome-specific reward memories. ” '''
+
<u>Title: </u> ''' “ Hippocampal-amygdala memory circuits govern experience-dependent observational fear ” '''
  
<u>Summary:</u> To make adaptive decisions, we often use cues in our environment to retrieve detailed memories of associated rewards and choose accordingly. Emerging evidence suggests ventral tegmental area (VTA) dopamine might be involved in learning the relationship between a cue and the identifying features of the specific reward it predicts (i.e., model-based learning). But the projections through which dopamine does this are unknown. Using optical imaging and manipulation methods coupled with the outcome-specific Pavlovian-to-instrumental transfer task, we investigate the contribution of dopaminergic projections to the basolateral amygdala in forming these detailed associative reward memories.  
+
<u>Summary:</u> The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior similar fear experience in the observer and social familiarity with the demonstrator. However, the neural circuit mechanisms of experience-dependent OF (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits in mice without involving the anterior cingulate cortex, considered a center of OF, mediate Exp OF. Dorsal HPC neurons generate fear memory engram cells in BLA encoding prior similar fear experiences, which are essential for Exp OF. On the other hand, ventral HPC neurons respond to the familiar demonstrator’s aversive situation during Exp OF, which reactivates the fear memory engram cells in BLA to elicit Exp OF. Our study provides new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like Exp OF.
  
<u>Relevant Papers:</u> https://elifesciences.org/articles/68617
+
<u>Relevant Papers:</u>   https://www.sciencedirect.com/science/article/pii/S0896627322000587
  
 
='''About Us'''=
 
='''About Us'''=
Line 26: Line 26:
 
Current Organizers:
 
Current Organizers:
  
[http://www.silvalab.org/lab_members.html Megha Sehgal] ([http://www.silvalab.org/ Silva Lab]) & [http://www.silvalab.org/lab_members.html Giselle Fernandes] ([http://www.silvalab.org/ Silva Lab]).  
+
[https://www.buonomanolab.com/ Saray Soldado] ([https://www.buonomanolab.com/ Buonomano Lab]) & [https://churchlandlab.org/ Lukas Oesch] ([https://churchlandlab.org/ Churchland Lab]).  
 
Please email us at '''iclm.journalclub@gmail.com''' if you would like to get regular updates regarding our journal club and weekly reminders.
 
Please email us at '''iclm.journalclub@gmail.com''' if you would like to get regular updates regarding our journal club and weekly reminders.
  
Line 51: Line 51:
  
 
viii) [http://www.physics.ucla.edu/~mayank/ Shonali Dhingra] ([http://www.physics.ucla.edu/~mayank/ Mehta Lab]) (2018-2020)
 
viii) [http://www.physics.ucla.edu/~mayank/ Shonali Dhingra] ([http://www.physics.ucla.edu/~mayank/ Mehta Lab]) (2018-2020)
 +
 +
ix) [http://silvalab.org/lab_members.html Megha Sehgal] ([http://silvalab.org/lab_members.html Silva Lab]) & [http://silvalab.org/lab_members.html Giselle Fernandes] ([http://silvalab.org/lab_members.html Silva Lab]) (2020-2022)
  
 
='''Wiki Newbies'''=
 
='''Wiki Newbies'''=

Latest revision as of 04:10, 13 July 2022

This Week - 10 June 2022 (9:30 a.m., via Zoom)

Speaker: Caitlin Goodpaster

Title: “ Hippocampal-amygdala memory circuits govern experience-dependent observational fear ”

Summary: The empathic ability to vicariously experience the other’s fearful situation, a process called observational fear (OF), is critical to survive in nature and function in society. OF can be facilitated by both prior similar fear experience in the observer and social familiarity with the demonstrator. However, the neural circuit mechanisms of experience-dependent OF (Exp OF) remain unknown. Here, we demonstrate that hippocampal-basolateral amygdala (HPC-BLA) circuits in mice without involving the anterior cingulate cortex, considered a center of OF, mediate Exp OF. Dorsal HPC neurons generate fear memory engram cells in BLA encoding prior similar fear experiences, which are essential for Exp OF. On the other hand, ventral HPC neurons respond to the familiar demonstrator’s aversive situation during Exp OF, which reactivates the fear memory engram cells in BLA to elicit Exp OF. Our study provides new insights into the memory engram-dependent perception-action coupling that underlies empathic behaviors like Exp OF.

Relevant Papers: https://www.sciencedirect.com/science/article/pii/S0896627322000587

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Saray Soldado (Buonomano Lab) & Lukas Oesch (Churchland Lab). Please email us at iclm.journalclub@gmail.com if you would like to get regular updates regarding our journal club and weekly reminders.

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

ix) Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab) (2020-2022)

Wiki Newbies

Consult the User's Guide for information on using the wiki software.