ICLM Journal Club

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This Week - 18 May 2018 (9:30 a.m., Gonda 1st Floor Conference Room)

Speaker: Nick Hardy

Title: Neural network dynamics of temporal processing

Abstract: Time is centrally involved in most tasks the brain performs. However, the neurobiological mechanisms of timing remain a mystery. A major question is whether timing is generated by a specialized clock in the brain or whether it is arises locally via the emergent dynamics of neural networks. I will present two studies examining the latter hypothesis, combining mathematical models, in vitro neural recordings, and human psychophysics to describe potential network level mechanisms for timing in the brain. The first study examines the mechanisms of producing the same complex movement at a variety of speeds, a fundamental feature of motor timing. This study combines theoretical and psychophysical experiments to predict and test a novel feature of motor timing: temporal accuracy improves with speed, termed the Weber-speed effect. The second study examines how cortical neural networks encode temporal information. Using organotypic slice cultures, this study demonstrates that the cortex processes temporal input patterns in a state dependent manner, supporting theoretical predictions. Taken together, the results of this work strongly support state dependent theories of timing, providing insight into the neural basis temporal processing.

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Shonali Dhingra & Helen Motanis

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

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