Difference between revisions of "ICLM Journal Club"

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(This Week - 18 November 2016 (9:30 a.m., Gonda 1st Floor Conference Room))
(This Week - 18 November 2016 (9:30 a.m., Gonda 1st Floor Conference Room))
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Speaker: '''Professor Wickliffe Abaraham (Professor and Co-Director of Brain Research, NZ, Department of Psychology, Brain Health Research Center University of Otago)'''
 
Speaker: '''Professor Wickliffe Abaraham (Professor and Co-Director of Brain Research, NZ, Department of Psychology, Brain Health Research Center University of Otago)'''
 
  
 
Title: '''Regulation of memory mechanisms by secreted amyloid precursor protein-α
 
Title: '''Regulation of memory mechanisms by secreted amyloid precursor protein-α

Revision as of 21:25, 14 November 2016

This Week - 18 November 2016 (9:30 a.m., Gonda 1st Floor Conference Room)

Speaker: Professor Wickliffe Abaraham (Professor and Co-Director of Brain Research, NZ, Department of Psychology, Brain Health Research Center University of Otago)

Title: Regulation of memory mechanisms by secreted amyloid precursor protein-α


Secreted amyloid precursor protein-α (sAPPα), generated by non-amyloidogenic cleavage of amyloid precursor protein, is neuroprotective, neurotrophic, neurogenic and facilitates LTP and memory. However the mechanisms of its action on LTP are poorly understood. Recently we have found that sAPPa facilitates trafficking of glutamate receptors to the cell surface and stimulates protein synthesis and there is a coupling between these events. These and other findings suggest that sAPPa may have therapeutic potential. Supporting this proposal, we have found using a gene therapy approach that sAPPa can rescue spatial memory and LTP deficits in a mouse model of Alzheimer’s disease.

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab)

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

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