Difference between revisions of "ICLM Journal Club"
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Title: ''' Humanin mimetics as potential candidates for modulation of learning and memory impairments''' | Title: ''' Humanin mimetics as potential candidates for modulation of learning and memory impairments''' | ||
Revision as of 17:15, 23 February 2017
This Week - 24 February 2017 (9:30 a.m., Gonda 2nd Floor Conference Room)
Speaker: Mohammad-Parvez Alam
Title: Humanin mimetics as potential candidates for modulation of learning and memory impairments
Humanin (HN), a 24-amino acid bioactive peptide that exerts its effects through gp130 interaction, increases cell survival after exposure to Abeta and NMDA-induced toxicity. HN and its analog have also been shown to ameliorate the learning and memory impairment induced by scopolamine and diazepam. However, HN due to its peptidic structure presents challenges in its development as a therapeutic drug. Therefore, a small molecule gp130 agonist mimetic of HN would allow for more rapid development and ease of delivery into the brain. We have designed and synthesized analogs of the gp130 agonist (identified through screening) and conducted an exploratory medicinal chemistry structure-activity relationship (SAR) to identify small-molecule humanin mimetics as lead candidate(s). Continuous flow-chemistry was used to facilitate syntheses of new analogs as it allows a green-chemistry approach for synthesis and SAR optimization. The analogs generated has enabled us to gain chemical insights into the SAR and elucidated the potential of a small molecule gp130 agonist to protect against learning and memory impairments.
About Us
Introduction
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Organizers:
Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab)
Current Faculty Advisor:
Past Organizers:
i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)
ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)
iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)
iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)
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