Difference between revisions of "ICLM Journal Club"

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Current Organizers:
 
Current Organizers:
  
[http://www.researchgate.net/profile/Walter_Babiec/ Walt Babiec] ([http://faculty.bri.ucla.edu/institution/personnel?personnel_id=46704 O'Dell Lab]) & [http://www.neurobio.ucla.edu/~dbuono/lab_members.htm Helen Motanis] ([http://www.neurobio.ucla.edu/~dbuono/index.html Buonomano Lab])
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[http://www.buonomanolab.com/ Dean Buonomano] & [http://www.neurobio.ucla.edu/~dbuono/lab_members.htm Helen Motanis] ([http://www.neurobio.ucla.edu/~dbuono/index.html Buonomano Lab])
  
 
Current Faculty Advisor:
 
Current Faculty Advisor:
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iv) [http://www.silvalab.org/lab_members/current_lab_members.html Justin Shobe] & [http://med.stanford.edu/profiles/postdocs/researcher/Thomas_Rogerson/ Thomas Rogerson] (Dec 2011 - June 2013) ([http://www.silvalab.org Silva Lab])
 
iv) [http://www.silvalab.org/lab_members/current_lab_members.html Justin Shobe] & [http://med.stanford.edu/profiles/postdocs/researcher/Thomas_Rogerson/ Thomas Rogerson] (Dec 2011 - June 2013) ([http://www.silvalab.org Silva Lab])
  
v) Walt Babiec (2013-2014)
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v) [http://www.researchgate.net/profile/Walter_Babiec/ Walt Babiec] ([http://faculty.bri.ucla.edu/institution/personnel?personnel_id=46704 O'Dell Lab]) (2013-2014)
  
vi) Walt Babiec and Helen Motanis (2014-2017)
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vi) [http://www.researchgate.net/profile/Walter_Babiec/ Walt Babiec] ([http://faculty.bri.ucla.edu/institution/personnel?personnel_id=46704 O'Dell Lab]) & [http://www.neurobio.ucla.edu/~dbuono/lab_members.htm Helen Motanis] ([http://www.neurobio.ucla.edu/~dbuono/index.html Buonomano Lab]) (2014-2017)
  
 
='''Wiki Newbies'''=
 
='''Wiki Newbies'''=

Revision as of 16:09, 6 October 2017

This Week - 12 May 2017 (9:30 a.m., Gonda 2nd Floor Conference Room)

Speaker: Dean Buonomano

Title: Beyond Hebb: Associative Plasticity on the Scale of Seconds

Behavioral time scale synaptic plasticity underlies CA1 place fields Authors: Bittner, Milstein, Grienberger, Romani, and Magee. Bittner et al, Science 2017

Abstract: How do synaptic or other neuronal changes support learning? This subject has been dominated by Hebb's postulate of synaptic change. Although there is strong experimental support for Hebbian plasticity in a number of preparations, alternative ideas have also been developed over the years. Bittner et al. provide in vivo, in vitro, and modeling data to support the view that non-Hebbian plasticity may underlie the formation of hippocampal place fields (see the Perspective by Krupic). Instead of multiple pairings, a single strong Ca2+ plateau potential in neuronal dendrites paired with spatial inputs may be sufficient to produce place cells.Science, this issue p. 1033; see also p. 974Learning is primarily mediated by activity-dependent modifications of synaptic strength within neuronal circuits. We discovered that place fields in hippocampal area CA1 are produced by a synaptic potentiation notably different from Hebbian plasticity. Place fields could be produced in vivo in a single trial by potentiation of input that arrived seconds before and after complex spiking. The potentiated synaptic input was not initially coincident with action potentials or depolarization. This rule, named behavioral time scale synaptic plasticity, abruptly modifies inputs that were neither causal nor close in time to postsynaptic activation. In slices, five pairings of subthreshold presynaptic activity and calcium (Ca2+) plateau potentials produced a large potentiation with an asymmetric seconds-long time course. This plasticity efficiently stores entire behavioral sequences within synaptic weights to produce predictive place cell activity.

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Dean Buonomano & Helen Motanis (Buonomano Lab)

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

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