Difference between revisions of "ICLM Journal Club"

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(This Week - 15 March 2019 (9:30 a.m., Gonda 5th Floor Conference Room))
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<u>Relevant Paper(s):</u> A review paper pertaining to this sub-field of 'learning and memory'
 
<u>Relevant Paper(s):</u> A review paper pertaining to this sub-field of 'learning and memory'
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https://www.sciencedirect.com/science/article/pii/S0091305701006852?via%3Dihub
 
https://www.sciencedirect.com/science/article/pii/S0091305701006852?via%3Dihub
  

Revision as of 21:39, 12 March 2019

This Week - 15 March 2019 (9:30 a.m., Gonda 5th Floor Conference Room)

Speaker: Avishek Adhikari

Title: Hypothalamic control of organized escape from multimodal threats

Abstract: Circuits mediating escape from imminent threats such as close predatory encounters are strongly implicated in the generation of panic attacks. Naturalistic escape from threats occur in complex environments in which animals must quickly flee through the most efficient route. Prior studies have identified regions that produce escape-related movements, such as aimless running and jumping, but these reports did not identify circuits that control organized escape by choosing optimal escape routes. We identify the hypothalamic dorsal premammillary nucleus (PMd) as a key, previously unrecognized site that mediates organized, complex escape. PMd stimulation in an empty box causes escape jumps, but PMd stimulation in a box with a complex escape climbing route causes climbing not jumping. In contrast, stimulation of other hypothalamic or brainstem sites implicated in escape causes aimless running and jumping regardless of the availability of efficient, though complex escape routes. We show that chemogenetic PMd inhibition impairs escape from a live predator, carbon dioxide, a heated floor and a shocking grid, while PMd excitation has the opposite effect. We also find that PMd neural activity increases before escape from a wide variety of innate threats, regardless of the specific motor actions needed to escape. Lastly, we show that the PMd projection to the brainstem periaqueductal gray region mediates these effects. These results identify the PMd as a novel circuit that controls organized escape behaviors induced by threats. These findings increase understanding of adaptive escape to threats in naturalistic situations and may also illuminate mechanisms underlying panic attacks.

Relevant Paper(s): A review paper pertaining to this sub-field of 'learning and memory'

https://www.sciencedirect.com/science/article/pii/S0091305701006852?via%3Dihub

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Shonali Dhingra

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

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