ICLM Journal Club

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This Week - 22 May 2020 (9:30 a.m., via ZOOM)

Speaker: Ana Sias

Title: “A reciprocal cortical-amygdala circuit for the encoding and retrieval of detailed associative reward memories”

Abstract: Every day we use cues in our environment to infer the availability of prospective rewards and guide reward seeking. Adaptive decision making thus relies on our ability to use learned stimulus-outcome (S-O) relationships to represent potential available outcomes. But little is known about the neural circuits that mediate the learning and subsequent retrieval of these S-O memories to guide choice. Such information will be pertinent to our understanding of disease states in which a failure to accurately form or recall these associative memories can result in maladaptive behavior. To address this, here we use optogenetics, chemogenetics, and serial circuit disconnection, providing evidence for a reciprocally connected lOFC->BLA->lOFC circuit crucial for the encoding and subsequent retrieval of detailed stimulus-outcome memories.

Relevant Paper(s): Ana will be presenting unpublished data, built off of previous work from the Wassum lab https://www.jneurosci.org/content/37/35/8374

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Shonali Dhingra

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

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