Difference between revisions of "ICLM Journal Club"

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(This Week - 8 May 2020 (9:30 a.m., via ZOOM))
(This Week - 15 May 2020 (9:30 a.m., via ZOOM))
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=<font color="blue">'''This Week - 15 May 2020 (9:30 a.m., via ZOOM)'''</font>=
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=<font color="blue">'''This Week - 22 May 2020 (9:30 a.m., via ZOOM)'''</font>=
  
<u>Speaker:</u> ''' André Sousa '''
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<u>Speaker:</u> ''' Ana Sias '''
  
<u>Title:</u> “Thirst regulates motivated behavior through modulation of brainwide neural population dynamics”
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<u>Title:</u> “A reciprocal cortical-amygdala circuit for the encoding and retrieval of detailed associative reward memories”
  
<u>Abstract:</u> Physiological needs produce motivational drives, such as thirst and hunger, that regulate behaviors essential to survival. Hypothalamic neurons sense these needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior. We studied dynamics from ~24,000 neurons in 34 brain regions during thirst-motivated choice behavior in 21 mice as they consumed water and became sated. Water-predicting sensory cues elicited activity that rapidly spread throughout the brain of thirsty animals. These dynamics were gated by a brainwide mode of population activity that encoded motivational state. After satiation, focal optogenetic activation of hypothalamic thirst-sensing neurons returned global activity to the pre-satiation state. Thus, motivational states specify initial conditions that determine how a brainwide dynamical system transforms sensory input into behavioral output.
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<u>Abstract:</u> Every day we use cues in our environment to infer the availability of prospective rewards and guide reward seeking. Adaptive decision making thus relies on our ability to use learned stimulus-outcome (S-O) relationships to represent potential available outcomes. But little is known about the neural circuits that mediate the learning and subsequent retrieval of these S-O memories to guide choice. Such information will be pertinent to our understanding of disease states in which a failure to accurately form or recall these associative memories can result in maladaptive behavior. To address this, here we use optogenetics, chemogenetics, and serial circuit disconnection, providing evidence for a reciprocally connected lOFC->BLA->lOFC circuit crucial for the encoding and subsequent retrieval of detailed stimulus-outcome memories.
  
<u>Relevant Paper(s):</u> https://science.sciencemag.org/content/364/6437/eaav3932
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<u>Relevant Paper(s):</u> Ana will be presenting unpublished data, built off of previous work from the Wassum lab https://www.jneurosci.org/content/37/35/8374
  
 
='''About Us'''=
 
='''About Us'''=

Revision as of 10:43, 20 May 2020

This Week - 22 May 2020 (9:30 a.m., via ZOOM)

Speaker: Ana Sias

Title: “A reciprocal cortical-amygdala circuit for the encoding and retrieval of detailed associative reward memories”

Abstract: Every day we use cues in our environment to infer the availability of prospective rewards and guide reward seeking. Adaptive decision making thus relies on our ability to use learned stimulus-outcome (S-O) relationships to represent potential available outcomes. But little is known about the neural circuits that mediate the learning and subsequent retrieval of these S-O memories to guide choice. Such information will be pertinent to our understanding of disease states in which a failure to accurately form or recall these associative memories can result in maladaptive behavior. To address this, here we use optogenetics, chemogenetics, and serial circuit disconnection, providing evidence for a reciprocally connected lOFC->BLA->lOFC circuit crucial for the encoding and subsequent retrieval of detailed stimulus-outcome memories.

Relevant Paper(s): Ana will be presenting unpublished data, built off of previous work from the Wassum lab https://www.jneurosci.org/content/37/35/8374

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Shonali Dhingra

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

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