Difference between revisions of "ICLM Journal Club"
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=<font color="blue">'''This Week -
=<font color="blue">'''This Week - October 2020 (9:30 a.m., via Zoom)'''</font>=
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Revision as of 06:24, 28 October 2020
This Week - 30 October 2020 (9:30 a.m., via Zoom)
Speaker: David Glanzman
Title: “Behavioral tagging underlies memory reconsolidation”
Abstract: Authors (We) studied how novel events contiguous to memory retrieval affect the process of memory updating termed reconsolidation. We show that memory retrieval sets a neuronal tag to which proteins provided by the novel events can bind, restabilizing thereby memory via a behavioral-tagging mechanism. Our results thus indicate that the different phases of memory stabilization (consolidation, extinction, and now reconsolidation) are mediated by behavioral tagging, which emerges as a general mechanism of long-term memory formation. They provide, in addition, a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) existing memories via their reactivation with novel experiences.
Relevant Paper(s): https://www.pnas.org/content/117/30/18029
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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