Difference between revisions of "ICLM Journal Club"

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=<font color="blue">'''This Week - 20 November 2020 (9:30 a.m., via Zoom)'''</font>=
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=<font color="blue">'''This Week - 04 December 2020 (9:30 a.m., via Zoom)'''</font>=
  
<u>Speaker:</u> ''' Paul Mathews '''
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<u>Speaker:</u> ''' Daniel Aharoni'''
  
<u>Title:</u> “Bidirectional control of fear memories by cerebellar neurons projecting to the ventrolateral periaqueductal grey”
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<u>Title:</u> “Developing new tools for imaging network dynamics in freely behaving animals”
  
<u>Abstract:</u> Fear conditioning is a form of associative learning that is known to involve different brain areas, notably the amygdala, the prefrontal cortex and the periaqueductal grey (PAG). Here, we describe the functional role of pathways that link the cerebellum with the fear network. We found that the cerebellar fastigial nucleus (FN) sends glutamatergic projections to vlPAG that synapse onto glutamatergic and GABAergic vlPAG neurons. Chemogenetic and optogenetic manipulations revealed that the FN-vlPAG pathway controls bi-directionally the strength of the fear memories, indicating an important role in the association of the
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<u>Abstract:</u> One of the biggest challenges in neuroscience is to understand how neural circuits in the brain process, encode, store, and retrieve information. Meeting this challenge requires tools capable of recording and manipulating the activity of intact neural networks in freely behaving animals. Head-mounted miniature fluorescence microscopes are among the most promising of these tools. Taking advantage of the past decade of advancements in fluorescent neural activity reports, these microscopes use wide-field single photon excitation to image activity across large populations of neurons in freely behaving animals. They are capable of imaging the same neural population across months and in a wide range of different brain regions.
conditioned and unconditioned stimuli, a function consistent with vlPAG encoding of fear prediction error. Moreover, FN-vlPAG projections also modulate extinction learning. We also found a FN-parafascicular thalamus pathway, which may relay cerebellar influence to the amygdala and modulates anxiety behaviors. Overall, our results reveal multiple contributions of the cerebellum to the emotional system.
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<u>Blurb:</u> Way back in 1987 Michael Fanselow demonstrated that lesions of the rat cerebellar vermis caused a decrease in the expression of fear. This Friday we will discuss a recent article providing a likely circuit mechanism for this result, demonstrating that neurons in the cerebellar fastigial nucleus monosynaptically project to the ventrolateral periaqueductal grey and have the capability of bi-directionally controlling fear expression.   
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Initiated six years ago, the Miniscope Project -- an open-source collaborative effort-- aims at accelerating innovation of miniature microscope technology while also extending access to this technology to the entire neuroscience community. Currently, we are working on advancements ranging from optogenetic stimulation and wire-free operation to simultaneous optical and electrophysiology recording. Through continued optimization and innovation, miniature microscopes will likely play a critical role in extending the reach of neuroscience research and creating new avenues of scientific inquiry.   
  
<u>Relevant Paper(s):</u>  https://www.nature.com/articles/s41467-020-18953-0#Sec16
 
  
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<u>Relevant Paper(s):</u>  https://www.nature.com/articles/nature17955
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https://www.nature.com/articles/s41593-019-0559-0
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https://www.nature.com/articles/s41592-018-0266-x
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miniscope.org
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https://github.com/Aharoni-Lab/Miniscope-v4/wiki
  
 
='''About Us'''=
 
='''About Us'''=

Revision as of 23:53, 2 December 2020

This Week - 04 December 2020 (9:30 a.m., via Zoom)

Speaker: Daniel Aharoni

Title: “Developing new tools for imaging network dynamics in freely behaving animals”

Abstract: One of the biggest challenges in neuroscience is to understand how neural circuits in the brain process, encode, store, and retrieve information. Meeting this challenge requires tools capable of recording and manipulating the activity of intact neural networks in freely behaving animals. Head-mounted miniature fluorescence microscopes are among the most promising of these tools. Taking advantage of the past decade of advancements in fluorescent neural activity reports, these microscopes use wide-field single photon excitation to image activity across large populations of neurons in freely behaving animals. They are capable of imaging the same neural population across months and in a wide range of different brain regions.

Initiated six years ago, the Miniscope Project -- an open-source collaborative effort-- aims at accelerating innovation of miniature microscope technology while also extending access to this technology to the entire neuroscience community. Currently, we are working on advancements ranging from optogenetic stimulation and wire-free operation to simultaneous optical and electrophysiology recording. Through continued optimization and innovation, miniature microscopes will likely play a critical role in extending the reach of neuroscience research and creating new avenues of scientific inquiry.


Relevant Paper(s): https://www.nature.com/articles/nature17955 https://www.nature.com/articles/s41593-019-0559-0 https://www.nature.com/articles/s41592-018-0266-x miniscope.org https://github.com/Aharoni-Lab/Miniscope-v4/wiki

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab)

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

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