Difference between revisions of "ICLM Journal Club"
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<u>Relevant papers:</u> https://www.nature.com/articles/s41586-021-
<u>Relevant papers:</u> https://www.nature.com/articles/s41586-021--
Revision as of 18:51, 11 February 2022
This Week - 11 February 2022 (9:30 a.m., via Zoom)
Speaker: Lukas Oesch
Title: “ Mouse prefrontal cortex represents learned rules for categorization ”
Summary:How animals learn to classify a set of stimuli into discrete categories that can guide the selection of adequate behavioral responses remains poorly understood. One of the major challenges in identifying the neural representation of such categories is that they might partially overlap with other representations, such as stimulus identity or chosen actions. In their study Reinert and colleagues recorded neural activity in the mouse prefrontal cortex while animals were learning a visual Go/NoGo task. They demonstrate the presence of category selective neurons by changing either the categorization rule on a constant set of stimuli or the way animals reported their choice. They further show that category selectivity for Go-associated stimuli arises earlier in learning than NoGo-category selectivity.
Relevant papers: https://www.nature.com/articles/s41586-021-03452-z
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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