ICLM Journal Club
This Week - 18 March 2022 (9:30 a.m., via Zoom)
Speaker: Zachary Zeidler
Title: “ Memory organization in the amygdala across time and re-exposure. ”
Summary: I will discuss and synthesize two recent papers examining amygdalar activity during fear memory across time and memory re-exposure. The papers emphasize different aspects of amygdala dynamics. One paper (Liu...Maren Jan 2022 Biol Psych) focuses on overlap in activity representing both recent and remote memory. The other (Cho...Han Dec 2021 Curr Bio) emphasizes turnover in amygdalar ensembles following memory re-exposure. Together, they show the persistent yet dynamic activity of amygdalar ensembles in fear memory
1) Liu, J., Totty, M. S., Melissari, L., Bayer, H. & Maren, S. Convergent coding of recent and remote fear memory in the basolateral amygdala. Biol Psychiat (2022) doi:10.1016/j.biopsych.2021.12.018.
2) Cho, H.-Y. et al. Turnover of fear engram cells by repeated experience. Curr Biol (2021) doi:10.1016/j.cub.2021.10.004.
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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