Difference between revisions of "ICLM Journal Club"

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(→‎This Friday - October 28, 2022 (9:30 a.m., in person, Gonda 1357))
(→‎This Friday - October 28, 2022 (9:30 a.m., in person, Gonda 1357))
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=<font color="blue">'''This Friday - October 28, 2022 (9:30 a.m., in person, Gonda 1357)'''</font>=
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=<font color="blue">'''No ICLM journal club this Friday. We'll be back on November 18!'''</font>=
  
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<u>Speaker:</u> ''David Glanzman''
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<u>Speaker:</u> '' ''
  
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<u>Title:</u> '''Uncovering long-term existence of a silent short-term memory trace'''
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<u>Title:</u> ''' '''
  
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<u>Summary:</u> Active recall of short-term memory (STM) is known to last for a few hours, but whether STM has long-term functions is unknown. Here we show that, STM can be optogenetically retrieved at a time point during which natural recall is not possible, uncovering the long-term existence of a silent STM engram. Moreover, re-training within 3 days led to natural long-term recall, indicating facilitated consolidation. Calcium imaging revealed hippocampal CA1 reactivations of the STM trace during post-learning sleep. Inhibiting offline CA1 activity, N-methyl-D-aspartate receptor activity, or protein synthesis after first exposure to the STM-forming event impaired the future re-exposure-facilitated consolidation, which highlights a role of protein synthesis and sleep in storing a silent STM trace. These results provide evidence that STM is not completely lost within hours and demonstrates a possible two-step STM consolidation, first storage as a silent engram, then transformation into an active state by recurrence within 3 days.   
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<u>Summary:</u>  
  
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<u>Relevant Papers:</u> [https://www.biorxiv.org/content/10.1101/2021.05.08.443276v1 Uncovering long-term existence of a silent short-term memory trace, ''Maha E. Wally, Masanori Nomoto, Kareem Abdou, Kaoru Inokuchi, bioRxiv (2021)'']
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<u>Relevant Papers:</u>
  
 
='''About Us'''=
 
='''About Us'''=

Revision as of 20:24, 10 November 2022

No ICLM journal club this Friday. We'll be back on November 18!

Speaker:

Title:

Summary:

Relevant Papers:

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Saray Soldado (Buonomano Lab) & Lukas Oesch (Churchland Lab). Please email us at iclm.journalclub@gmail.com if you would like to get regular updates regarding our journal club and weekly reminders.

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

ix) Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab) (2020-2022)

Wiki Newbies

Consult the User's Guide for information on using the wiki software.


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