Difference between revisions of "Previous weeks"
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Revision as of 22:41, 27 April 2011
2011
January
February
Feb 25th
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title :A selective role for dopamine in stimulus–reward learning
Speaker: Michael Faneslow
Summary: Flagel et al Nature 469, 53–57 (06 January 2011)
Relevant Information:
March
Mar 4th
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title : Maladaptive Cortical Plasticity and Plasticity
Speaker: Dean Buonomano
Summary: Engineer ND, Riley JR, Seale JD, Vrana WA, Shetake JA, Sudanagunta SP, Borland MS, Kilgard MP (2011) Nature 470:101-104. Reversing pathological neural activity using targeted plasticity
Relevant Information:
Mar 11th
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title : Memory enhancement and PKM Zeta
Speaker: Yong-Seok Lee
Summary: Yong-Seok Lee will present the newest paper from the Dudai Lab regarding overexpression of PKM in the neocortex and its enhancement of LTM.
Relevant Information:
Mar 18th
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title : Notch Signaling
Speaker: Kelsey Martin
Summary: Notch signaling plays critical roles during the development of the nervous system. Several studies have suggested that Notch signaling in neurons is also involved in learning and memory and synaptic plasticity in the mature brain. However, these studies have been suggestive rather than conclusive. Moreover, studies from Ben Barres indicate that Notch receptor and ligands are expressed at very low levels in mature neurons, and at very high levels in glia. I will present a paper from Nick Gaiano's lab that argues that Notch signals from synapse to nucleus in mature hippocampal neurons and that this signaling is required for long-term potentiation and memory acquisition. Gaiano's data further indicates that the immediate early gene arc regulates Notch signaling in neurons.
The reference for the primary paper is:
Relevant Information:
April
01st Apr
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title : A critical role for IGF-II in memory consolidation and enhancement
Speaker: Ravi Ponnusamy
Summary: not provided
Relevant Information:
08th Apr
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title : The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP.
Speaker: Walter Babiec
Summary: The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage
Relevant Information:
Apr 15th
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title : Mushroom Body Output Neurons Encode Odor-Reward Associations
Speaker: David Glanzman
Summary: The paper describes neural correlates of odor representation and olfactory reward learning in honeybees using both population and single unit recording from the mushroom bodies.
Relevant Information: Paper