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Contents

2011

January

February

Feb 25th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title :A selective role for dopamine in stimulus–reward learning

Speaker: Michael Faneslow

Summary: Flagel et al Nature 469, 53–57 (06 January 2011)

Relevant Information:

Paper

Supp


March

Mar 4th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : Maladaptive Cortical Plasticity and Plasticity

Speaker: Dean Buonomano

Summary: Engineer ND, Riley JR, Seale JD, Vrana WA, Shetake JA, Sudanagunta SP, Borland MS, Kilgard MP (2011) Nature 470:101-104. Reversing pathological neural activity using targeted plasticity

Relevant Information:

Paper


Mar 11th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : Memory enhancement and PKM Zeta

Speaker: Yong-Seok Lee

Summary: Yong-Seok Lee will present the newest paper from the Dudai Lab regarding overexpression of PKM in the neocortex and its enhancement of LTM.


Relevant Information:

Paper


Mar 18th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : Notch Signaling

Speaker: Kelsey Martin

Summary: Notch signaling plays critical roles during the development of the nervous system. Several studies have suggested that Notch signaling in neurons is also involved in learning and memory and synaptic plasticity in the mature brain. However, these studies have been suggestive rather than conclusive. Moreover, studies from Ben Barres indicate that Notch receptor and ligands are expressed at very low levels in mature neurons, and at very high levels in glia. I will present a paper from Nick Gaiano's lab that argues that Notch signals from synapse to nucleus in mature hippocampal neurons and that this signaling is required for long-term potentiation and memory acquisition. Gaiano's data further indicates that the immediate early gene arc regulates Notch signaling in neurons.

The reference for the primary paper is:

Activity-induced notch signaling in neurons requires arc/arg3.1 and is essential for synaptic plasticity in hippocampal networks.

Relevant Information:

Paper

Review


April

01st Apr


Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : A critical role for IGF-II in memory consolidation and enhancement

Speaker: Ravi Ponnusamy

Summary: not provided

Relevant Information:

Paper


08th Apr


Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP.

Speaker: Walter Babiec

Summary: The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory, induced at some synapses facilitates L-LTP expression at other synapses receiving stimulation too weak to induce L-LTP by itself. Using glutamate uncaging and two-photon imaging, we demonstrate that the efficacy of this facilitation decreases with increasing time between stimulations, increasing distance between stimulated spines and with the spines being on different dendritic branches. Paradoxically, stimulated spines compete for L-LTP expression if stimulated too closely together in time. Furthermore, the facilitation is temporally bidirectional but asymmetric. Additionally, L-LTP formation is itself biased toward occurring on spines within a branch. These data support the Clustered Plasticity Hypothesis, which states that such spatial and temporal limits lead to stable engram formation, preferentially at synapses clustered within dendritic branches rather than dispersed throughout the dendritic arbor. Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage

Relevant Information:

Paper

Supp


Apr 15th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : Mushroom Body Output Neurons Encode Odor-Reward Associations

Speaker: David Glanzman

Summary: The paper describes neural correlates of odor representation and olfactory reward learning in honeybees using both population and single unit recording from the mushroom bodies.

Relevant Information: Paper


Apr 22nd

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title :From Drosophila olfaction to a general circuit model for behavioral habituation.

Speaker: Mani Ramaswami

Summary:

Relevant Information:


Date: Apr 27th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title :The role of Thorase in the surface expression of glutamate receptors and its implications for synaptic plasticity and behavior

Speaker: Adam Roberts

Summary: Zhang et al., 2011 indicate that the AAA+ ATPase Thorase is required for the internalization of AMPARs by dissociating the GRIP1-GluR2 interaction. Genetic manipulation of Thorase expression modifies the surface expression of GluR1 and GluR2 in an ATP-dependent manner. Thorase KO mice have enhanced LTP, deficits in LTD, and larger AMPAR-dependent currents. These alterations in nervous system function result in deficits in learning and memory.

Relevant Information:

Paper


May

Date: May 13th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title :The role of Thorase in the surface expression of glutamate receptors and its implications for synaptic plasticity and behavior

Speaker: Adam Roberts

Summary: Zhang et al., 2011 indicate that the AAA+ ATPase Thorase is required for the internalization of AMPARs by dissociating the GRIP1-GluR2 interaction. Genetic manipulation of Thorase expression modifies the surface expression of GluR1 and GluR2 in an ATP-dependent manner. Thorase KO mice have enhanced LTP, deficits in LTD, and larger AMPAR-dependent currents. These alterations in nervous system function result in deficits in learning and memory.

Relevant Information:

Paper


Date: May 17th

Time 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title: Action-Potential Modulation During Axonal Conduction

Speaker: Besim Ugzil"

Summary: Once initiated near the soma, an action potential (AP) is thought to propagate autoregeneratively and distribute uniformly over axonal arbors. We challenge this classic view by showing that APs are subject to waveform modulation while they travel down axons. Using fluorescent patch-clamp pipettes, we recorded APs from axon branches of hippocampal CA3 pyramidal neurons ex vivo. The waveforms of axonal APs increased in width in response to the local application of glutamate and an adenosine A1 receptor antagonist to the axon shafts, but not to other unrelated axon branches. Uncaging of calcium in periaxonal astrocytes caused AP broadening through ionotropic glutamate receptor activation. The broadened APs triggered larger calcium elevations in presynaptic boutons and facilitated synaptic transmission to postsynaptic neurons. This local AP modification may enable axonal computation through the geometry of axon wiring.

Releavant Information:

Paper


Date: May 17th

Time 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title: Action-Potential Modulation During Axonal Conduction

Speaker: Besim Ugzil"

Summary: Once initiated near the soma, an action potential (AP) is thought to propagate autoregeneratively and distribute uniformly over axonal arbors. We challenge this classic view by showing that APs are subject to waveform modulation while they travel down axons. Using fluorescent patch-clamp pipettes, we recorded APs from axon branches of hippocampal CA3 pyramidal neurons ex vivo. The waveforms of axonal APs increased in width in response to the local application of glutamate and an adenosine A1 receptor antagonist to the axon shafts, but not to other unrelated axon branches. Uncaging of calcium in periaxonal astrocytes caused AP broadening through ionotropic glutamate receptor activation. The broadened APs triggered larger calcium elevations in presynaptic boutons and facilitated synaptic transmission to postsynaptic neurons. This local AP modification may enable axonal computation through the geometry of axon wiring.

Relevant Information:

Paper


Date: May 27th

Time 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title: "What makes a place cell?"

Speaker: Justin Shobe"

Summary: Once initiated near the soma, an action potential (AP) is thought to propagate autoregeneratively and distribute uniformly over axonal arbors. We challenge this classic view by showing that APs are subject to waveform modulation while they travel down axons. Using fluorescent patch-clamp pipettes, we recorded APs from axon branches of hippocampal CA3 pyramidal neurons ex vivo. The waveforms of axonal APs increased in width in response to the local application of glutamate and an adenosine A1 receptor antagonist to the axon shafts, but not to other unrelated axon branches. Uncaging of calcium in periaxonal astrocytes caused AP broadening through ionotropic glutamate receptor activation. The broadened APs triggered larger calcium elevations in presynaptic boutons and facilitated synaptic transmission to postsynaptic neurons. This local AP modification may enable axonal computation through the geometry of axon wiring.

Releavant Information: Paper


June


Date: Jun 17th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : "Insulin Signaling and Dietary Restriction Differentially Influence the Decline of Learning and Memory with Age"

Speaker: Kelsey Martin

Summary: This paper from Coleen Murphy's lab at Princeton describes a novel assay for short and long-term associative memory in the worm c. elegans. Using this assay, the authors show that long-term memory declines very early in c elegans, before any deficits in chemotaxis or motility. Analysis of genetic mutants identifies a specific role for CREB during long-term memory, and further reveals that long-term memory is differentially regulated by the insulin/IGF-1 and dietary restriction longevity pathways.

Relevant Information:

Paper


July



Date: Jul 08th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : "The Origin of Time (in the Songbird Motor Pathway)"

Speaker: Michael A. Long

Summary: Not Provided

Relevant Information:

Lab Homepage



Date: Jul 22nd

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : ""Maps for navigating published work and informing experiment planning""

Speaker: Alcino J Silva and Anthony Landreth

Summary: The increasing volume and complexity of published studies in neuroscience have made it difficult to determine what is known, what is uncertain, and how to contribute effectively to one’s field. Therefore, there is a pressing need for strategies to derive simplified useful representations (i.e. maps) of previous findings and to help experiment planning. Toward these goals, we introduce a framework for classifying experiments and an approach for integrating experimental results based on implicit and explicit research practices in molecular and cellular studies of cognitive function. The development and explicit use of approaches like this one will enable researchers to systematically identify convergent evidence critical for assembling maps of published information. These maps will not only provide succinct summaries of published information, they will also be invaluable during experiment planning.

Relevant Information:

Internally circulated PDF (check your LMP email)


Previous Semesters

Winter 2010

Fall 2010

Summer 2010

Spring 2010

Fall 2009