ICLM Journal Club
This Week - 29 May 2020 (9:30 a.m., via ZOOM)
Speaker: Peter Schuette
Title: “Long-term characterization of hippocampal remapping during contextual fear acquisition and extinction”
Abstract: Hippocampal CA1 place cell spatial maps are known to alter their firing properties in response to contextual fear conditioning—a process called ‘remapping.’ In the present study, we use chronic calcium imaging to examine contextual fear-induced remapping over an extended period of time and with thousands of neurons, and we demonstrate that hippocampal ensembles encode space at a finer scale following contextual fear conditioning. This effect is strongest near the shock grid. We also characterize the long- term effects of shock on place cell ensemble stability, demonstrating that shock delivery induces a several day period of high fear and low between-session place field stability, followed by a new, stable spatial representation that appears after behavioral extinction of conditioned fear. Finally, we identify a novel group of CA1 neurons that robustly encode freeze behavior independently from spatial location. Thus, following fear conditioning, hippocampal CA1 place cells sharpen their spatial tuning and dynamically change spatial encoding stability throughout fear learning and extinction.
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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