ICLM Journal Club

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This Week - 20 October 2017 (9:30 a.m., Gonda 2nd Floor Conference Room)

Speaker: Nazim Kourdougli

Title: The dorsal subiculum as a “detour” to retrieve episodic memory

Abstract: The memory of a new experience is stored in neuronal ensembles distributed across several microcircuits of the hippocampal formation and other brain structures. These neuronal clusters may store different aspects of the episodic memory, such as “what” is the information stored and its emotional context (e.g. “where” and “when” a particular event occurred). When these memories are retrieved, the neuronal ensemble originally activated is then recalled. In a recent study published in Cell, S. Tonegawa’s lab shows that dorsal subiculum and the circuit, CA1 to dorsal subiculum to medial entorhinal cortex layer 5, play a crucial role selectively in the retrieval of episodic memories. Conversely, the direct CA1 to medial entorhinal cortex layer 5 circuit is essential specifically for memory formation. These data suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated with recall such as rapid memory updating and retrieval-driven instinctive fear responses. Overall, this report identified a two-circuit system underpinning the capacity of the hippocampus to integrate the “what”, “when” and “where” of episodic memory capacity.

Paper: http://www.cell.com/cell/fulltext/S0092-8674(17)30820-6

About Us


The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Shonali Dhingra & Helen Motanis

Current Faculty Advisor:

Dean Buonomano

Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

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