ICLM Journal Club
This Week - 16 April 2021 (9:30 a.m., via Zoom)
Speaker: Garrett Blair
Title: “ Wide field hippocampal imaging during an aversive learning experience ”
Abstract: Studies of hippocampal place cells show that they will remap their place fields in response to aversive or fearful stimuli. It is not well understood why this remapping occurs, but previous research suggests it can provide an orthogonal map onto which the novel information can be bound to. To address the nature of this aversive remapping, we utilized calcium imaging in the dorsal CA1 region of the rat hippocampus acquired with a novel large field of view miniature microscope (“LFOV miniscope”). Following aversive learning we see pronounced remapping near the shock location. We will discuss the ongoing project and results to receive feedback on future analysis and directions.
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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