Difference between revisions of "ICLM Journal Club"

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(This Friday - March 3, 2023 (9:30 a.m., in person, Gonda 1357))
(This Friday - June 9, 2023 (9:30 a.m., in person, Gonda 1357))
 
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=<font color="blue">'''This Friday - March 10, 2023 (9:30 a.m., in person, Gonda 2303)'''</font>=
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=<font color="blue">'''Summer break - The ICLM journal club will be back in October'''</font>=
  
<u>Speaker:</u> ''Gabriel Rojas Bowe''
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<u>Speaker:</u>  
  
<u>Title:</u> '''Thalamus-driven functional populations in frontal cortex support decision-making'''
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<u>Title:</u>  
  
<u>Summary:</u> Neurons in frontal cortex exhibit diverse selectivity representing sensory, motor and cognitive variables during decision-making. The neural circuit basis for this complex selectivity remains unclear. We examined activity mediating a tactile decision in mouse anterior lateral motor cortex in relation to the underlying circuits. Contrary to the notion of randomly mixed selectivity, an analysis of 20,000 neurons revealed organized activity coding behavior. Individual neurons exhibited prototypical response profiles that were repeatable across mice. Stimulus, choice and action were coded nonrandomly by distinct neuronal populations that could be delineated by their response profiles. We related distinct selectivity to long-range inputs from somatosensory cortex, contralateral anterior lateral motor cortex and thalamus. Each input connects to all functional populations but with differing strength. Task selectivity was more strongly dependent on thalamic inputs than cortico-cortical inputs. Our results suggest that the thalamus drives subnetworks within frontal cortex coding distinct features of decision-making.
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<u>Summary:</u>
  
<u>Relevant Papers:</u> [https://www.nature.com/articles/s41593-022-01171-w Thalamus-driven functional populations in frontal cortex support decision-making, ''Weiguo Yang, Sri Laasya Tipparaju, Guang Chen & Nuo Li, Nat Neurosci (2022)]
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<u>Relevant Paper:</u>
  
 
='''About Us'''=
 
='''About Us'''=

Latest revision as of 02:30, 15 June 2023

Summer break - The ICLM journal club will be back in October

Speaker:

Title:

Summary:

Relevant Paper:

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Saray Soldado (Buonomano Lab) & Lukas Oesch (Churchland Lab). Please email us at iclm.journalclub@gmail.com if you would like to get regular updates regarding our journal club and weekly reminders.

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

ix) Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab) (2020-2022)

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