Difference between revisions of "ICLM Journal Club"

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(No ICLM journal club this week, see you next Friday!)
(This Friday - June 9, 2023 (9:30 a.m., in person, Gonda 1357))
 
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=<font color="blue">'''This Friday - March 24, 2023 (9:30 a.m., in person, Gonda 1357)'''</font>=
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=<font color="blue">'''Summer break - The ICLM journal club will be back in October'''</font>=
  
<u>Speaker:</u> ''Chinmay Purandare''
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<u>Speaker:</u>  
  
<u>Title:</u> '''Mega-scale movie-fields in the mouse visuo-hippocampal network'''
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<u>Title:</u>  
  
<u>Summary:</u> Natural behavior often involves a continuous series of related images, often while the subject is immobile. How is this information processed across the cortico-hippocampal circuit? The hippocampus is crucial for episodic memory, but most rodent single unit studies require spatial exploration or active engagement. Hence, we investigated neural responses to a silent, iso-luminant, black and white movie in head-fixed mice without any task or locomotion demands, or rewards. A third (33%, 3379/10263) of hippocampal –dentate gyrus, CA1 and subiculum– neurons showed movie-selectivity, with elevated firing in specific movie sub-segments, similar to visual areas. On average, a cell had more than 5 movie-fields (frames of movie corresponding to increased firing) in visual areas, but only 2 in hippocampal areas. The movie-field durations in all brain regions spanned an unprecedented 1000-fold range: from 0.02s to 20s, termed mega-scale coding. Presentation of the movie images in a scrambled sequence virtually abolished hippocampal but not visual-cortical selectivity. The enhancement of sequential movie tuning compared to the scrambled sequence was eight-fold greater in hippocampal than visual areas. Thus, a movie was encoded in all mouse-brain areas investigated and similar results are likely to hold in primates and humans. Hence, movies could provide a unified way to probe neural mechanisms of non-spatial information processing and memory across brain regions and species.
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<u>Summary:</u>
  
<u>Relevant Papers:</u> [https://elifesciences.org/reviewed-preprints/85069 Mega-scale movie-fields in the mouse visuo-hippocampal network, ''Chinmay S. Purandare & Mayank R. Mehta, eLife (2023)'']
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<u>Relevant Paper:</u>
 
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[https://www.nature.com/articles/s41586-022-04404-x Moving bar of light evokes vectorial spatial selectivity in the immobile rat hippocampus, ''Chinmay S. Purandare, Shonali Dhingra, Rodrigo Rios, Cliff Vuong, Thuc To, Ayaka Hachisuka, Krishna Choudhary & Mayank R. Mehta, Nature (2022)'']
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='''About Us'''=
 
='''About Us'''=

Latest revision as of 02:30, 15 June 2023

Summer break - The ICLM journal club will be back in October

Speaker:

Title:

Summary:

Relevant Paper:

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Saray Soldado (Buonomano Lab) & Lukas Oesch (Churchland Lab). Please email us at iclm.journalclub@gmail.com if you would like to get regular updates regarding our journal club and weekly reminders.

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

ix) Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab) (2020-2022)

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