Difference between revisions of "ICLM Journal Club"

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(→‎This Friday - June 2, 2023 (9:30 a.m., in person, Gonda 1357))
(→‎This Friday - June 9, 2023 (9:30 a.m., in person, Gonda 1357))
 
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=<font color="blue">'''This Friday - June 9, 2023 (9:30 a.m., in person, Gonda 1357)'''</font>=
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=<font color="blue">'''Summer break - The ICLM journal club will be back in October'''</font>=
  
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<u>Speaker:</u> ''Cassandra Klune''
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<u>Title:</u> '''Prefrontal Cortex Circuit Maturation and its Role in Adaptive Threat Avoidance'''
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<u>Summary:</u> The medial prefrontal cortex (mPFC) acts through its connections with the nucleus accumbens (NAc) and basolateral amygdala (BLA) to promote adaptive threat responses. To establish these mature cognitive functions, mPFC circuits undergo a prolonged development during which experience may feedback on the brain to promote adaptive responding. However, how the behavioral functions of mPFC circuits mature across development is poorly understood. Our study investigates the maturation of learned threat avoidance in mice and the contributions of mPFC-BLA and mPFC-NAc projections over development. Using platform mediated avoidance (PMA), in which a fear conditioned tone prompts rodents to navigate to a safety platform, we found that juvenile (postnatal day (P)23), adolescent (P35) and adult (P60+) mice were all able to learn PMA in a single training session. However, during a threat memory retrieval session the next day, adult mice showed robust avoidance memory, but P35 mice spent significantly less time on the platform and P23 mice displayed a rapid extinction response. To identify age-dependent differences in the underlying circuit function, we utilized optogenetic methods to manipulate mPFC-NAc and mPFC-BLA projections during the PMA retrieval session in mice trained at P23, P35 and P60+. In adults, excitation of mPFC-BLA neurons augmented avoidance while excitation of mPFC-NAc neurons reduced it. In contrast, at P23, excitation of mPFC-BLA neurons reduced avoidance. This suggests that mPFC-BLA neurons undergo circuit changes in early life that shape how they modulate avoidance behavior, potentially indicating a critical period in which disruption to circuit maturation may lead to maladaptive avoidance later on. At P35, inhibition of mPFC-NAc neurons increased avoidance, suggesting that mPFC-NAc neurons may be more active in adolescence, contributing to the lower levels of avoidance displayed by P35 mice. Together these findings indicate that the maturation of mPFC-BLA and mPFC-NAc circuits contributes to developmental changes in learned threat avoidance. Understanding how mPFC circuits develop in the typical brain will build an important foundation to understand how perturbed development may contribute to disease states.
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Latest revision as of 02:30, 15 June 2023

Summer break - The ICLM journal club will be back in October

Speaker:

Title:

Summary:

Relevant Paper:

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Saray Soldado (Buonomano Lab) & Lukas Oesch (Churchland Lab). Please email us at iclm.journalclub@gmail.com if you would like to get regular updates regarding our journal club and weekly reminders.

Current Faculty Advisor:

Dean Buonomano


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

ix) Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab) (2020-2022)

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