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| − | Date: Sep 02nd | + | Date: Sep 23rd |
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| | Time: 09:30 am | | Time: 09:30 am |
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| | Place : 2nd Floor Conference Room, Gonda building. | | Place : 2nd Floor Conference Room, Gonda building. |
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| − | <h4> Title : ""Prior experience modulates a natural threshold for memory formation ""</h4> | + | <h4> Title : ""2½ Short Stories of Pavlov's Flies""</h4> |
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| − | '''Speaker: Kiriana Cowansage ''' | + | '''Speaker: Steven de Belle''' |
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| − | Summary: Our current understanding of the molecular requirements for | + | Summary: Not provided |
| − | long–term memory come largely from studies that use experimental
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| − | manipulations to alter average behavior. Few studies, on the other
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| − | hand, have investigated the contribution of plasticity-related
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| − | proteins, like CREB, to existing behavioral differences in memory
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| − | strength that emerge naturally from genetically diverse populations.
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| − | In this talk I will begin by presenting work from the labs of Joe
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| − | LeDoux and Eric Klann (in collaboration with Sheena Josselyn) to
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| − | identify rats from a normally distributed group that fail to form
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| − | typical cued fear associations and express reduced baseline levels of
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| − | phospho-CREB. Memory in this subset of rats was selectively improved
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| − | by both pre-training exposure to contextual novelty and by virally
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| − | mediated enhancement of amygdala CREB activity. These results provide
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| − | some conceptual basis for current plans to investigate the cellular
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| − | dynamics of weak versus strong associative memory traces in the lab of
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| − | Mark Mayford, using a novel genetically encoded fluorescent timer
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| − | expressed in mice under the control of neural activity.
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| − | Relevant Information:
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| − | Subach et al (2009) Nat. Chem Biol
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