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Revision as of 15:43, 2 April 2014
This Week
Date: 04 April 2014
Time: 09:30 am
Place : Gonda 2nd Floor Conference Room
Title: Exosomes and Intercellular Signaling in the Brain
Speaker: Kelsey Martin
I'll focus on a research paper from Vivian Budnik's lab showing a role for exosomes in retrograde signaling at the fly neuromuscular junction, and provide some background from cell biological studies on the function of exosomes in transferring proteins and nucleic acids between cells. I've included a recent review from Holly Cline's lab that summarizes known functions of exosomes in neurological disease and injury, and addresses
possible roles for exosomes in normal brain development and functioning.
I think this is an emerging area of cell biology that is likely to be important to the biology of learning and memory.
Budnik Paper: Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release
Cline Review: Exosomes function in cell – cell communication during brain circuit development
About Us
Introduction
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Organizer:
Past Organizers:
i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)
ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)
iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)
iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)
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