Current events

Date: Nov 18th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title : " The h-currents, LTP,theta oscillations,grid cells and learning"

Speaker: Mayank Mehta

Summary: The hippocampal theta oscillations are thought to be critical for learning and memory and for the formation of entorhinal grid cells. Over the past few years the attention has been focused on the HCN1 channel: HCN1 channel knockout enhances theta rhythm and LTP, and improves spatial learning.

Two recent studies, one in the current issue of Neuron, from the Kandel lab, and another in the upcoming issue of Cell from the Moser lab, have measured the effect of HCN1 knockout on the entorhinal grid cells and hippocampal place cells, with many surprising results that compels us to rethink the cellular mechanisms governing grid cells and place cells.

Releavant Reading Material: http://www.sciencedirect.com/science?_ob=MiamiImageURL&_cid=272195&_user=4423&_pii=S0896627311007938&_check=y&_coverDate=2011-11-17&view=c&_gw=y&wchp=dGLzVlt-zSkzk&md5=9c0fb5a1be9056818c9b1daa13635cdf/1-s2.0-S0896627311007938-main.pdf