ICLM Journal Club
This Week
20 March 2015
Time: 09:30 am
Place : Gonda 2nd Floor Conference Room
Title: Ensemble dynamics in the lateral amygdala encode the formation of new fear memories
Speaker: Benjamin Grewe (Golshani Lab)
Previous research has investigated molecular, synaptic and cellular substrates of fear memory in the basolateral amygdala (BLA), but neural ensemble mechanisms underlying fear learning remain unknown. Using miniaturized imaging techniques we recorded neuronal ensembles in the BLA of freely moving mice and followed ensemble coding of conditioned and unconditioned stimuli throughout a multi day fear learning paradigm. We were able to show how aversive experiences during fear learning change the ensemble code of a neutral conditioned stimulus, to incorporate elements of aversive coding.
About Us
Introduction
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Organizers:
Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab)
Current Faculty Advisor:
Past Organizers:
i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)
ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)
iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)
iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)
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