Difference between revisions of "Current events"

From LMP Journal Club
Jump to: navigation, search
(No difference)

Revision as of 17:34, 9 May 2011

TDate: Apr 27th

Time: 09:30 am

Place : 2nd Floor Conference Room, Gonda building.

Title :The role of Thorase in the surface expression of glutamate receptors and its implications for synaptic plasticity and behavior

Speaker: Adam Roberts

Summary: Zhang et al., 2011 indicate that the AAA+ ATPase Thorase is required for the internalization of AMPARs by dissociating the GRIP1-GluR2 interaction. Genetic manipulation of Thorase expression modifies the surface expression of GluR1 and GluR2 in an ATP-dependent manner. Thorase KO mice have enhanced LTP, deficits in LTD, and larger AMPAR-dependent currents. These alterations in nervous system function result in deficits in learning and memory.

Relevant Information:

Paper