Difference between revisions of "ICLM Journal Club"

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(This Week)
(This Week)
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The paper doesn't present original experiments, but reanalyzes these data from these papers:
 
The paper doesn't present original experiments, but reanalyzes these data from these papers:
 
http://www.pnas.org/content/109/43/17687
 
http://www.pnas.org/content/109/43/17687
 +
 
http://www.nature.com/neuro/journal/v10/n6/full/nn1905.html
 
http://www.nature.com/neuro/journal/v10/n6/full/nn1905.html
 +
 
http://www.sciencemag.org/content/312/5774/758
 
http://www.sciencemag.org/content/312/5774/758
 +
 
http://www.nature.com/nature/journal/v436/n7052/full/nature03721.html
 
http://www.nature.com/nature/journal/v436/n7052/full/nature03721.html
  

Revision as of 16:43, 26 February 2014

This Week

Date: 28 February 2014

Time: 09:30 am

Place : Gonda 2nd Floor Conference Room

Title: Specific evidence of low-dimensional continuous attractor dynamics in grid cells

Speaker: Nick Hardy

I'll be presenting the paper "Specific evidence of low-dimensional continuous attractor dynamics in grid cells" by Yoon et al.

Abstract: We examined simultaneously recorded spikes from multiple rat grid cells, to explain mechanisms underlying their activity. Among grid cells with similar spatial periods, the population activity was confined to lie close to a two-dimensional (2D) manifold: grid cells differed only along two dimensions of their responses and otherwise were nearly identical. Relationships between cell pairs were conserved despite extensive deformations of single-neuron responses. Results from novel environments suggest such structure is not inherited from hippocampal or external sensory inputs. Across conditions, cell-cell relationships are better conserved than responses of single cells. Finally, the system is continually subject to perturbations that, were the 2D manifold not attractive, would drive the system to inhabit a different region of state space than observed. These findings have strong implications for theories of grid-cell activity and substantiate the general hypothesis that the brain computes using low-dimensional continuous attractors.

Relevant Materials:

The paper is found here

The paper doesn't present original experiments, but reanalyzes these data from these papers: http://www.pnas.org/content/109/43/17687

http://www.nature.com/neuro/journal/v10/n6/full/nn1905.html

http://www.sciencemag.org/content/312/5774/758

http://www.nature.com/nature/journal/v436/n7052/full/nature03721.html

The data from the last 2 papers can be publicly downloaded here: http://www.ntnu.edu/kavli/research/grid-cell-data

About Us

Introduction

The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizer:

Walt Babiec (O'Dell Lab)


Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

Wiki Newbies

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