ICLM Journal Club
This Week - 23 February 2018 (9:30 a.m., Gonda 2nd Floor Conference Room)
Speaker: Jason Moore
Title: Control of Hetero-synaptic Spike-Timing-Dependent Plasticity by Inhibition
Abstract: From Hiratani & Fukai, 2017: Recent experimental studies reveal that relative differences in spike timings experienced among neighboring glutamatergic and GABAergic synapses on a dendritic branch significantly influences changes in the efficiency of these synapses. This heterosynaptic form of spike-timing-dependent plasticity (STDP) is potentially important for shaping the synaptic organization and computation of neurons, but its functional role remains elusive. Through computational modeling at the parameter regime where previous experimental results are well reproduced, we show that heterosynaptic plasticity serves to finely balance excitatory and inhibitory inputs on the dendrite. Our results suggest a principle of GABA-driven neural circuit formation.
Papers: Modeling: Hiratani & Fukai, J. Neuroscience 2017: http://www.jneurosci.org/content/37/50/12106.long Experiment: Paille et al., J. Neuroscience 2013: http://www.jneurosci.org/content/33/22/9353
About Us
Introduction
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Organizers:
Shonali Dhingra & Helen Motanis
Current Faculty Advisor:
Past Organizers:
i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)
ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)
iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)
iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)
v) Walt Babiec (O'Dell Lab) (2013-2014)
vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)
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