Difference between revisions of "ICLM Journal Club"
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Revision as of 19:02, 13 December 2017
This Week - 15 December 2017 (9:30 a.m., Gonda 2nd Floor Conference Room)
Speaker: Paul Mathews
Title: Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice
Abstract: Contrary to long standing paradigms on cerebellar function that define it as a purely motor control center, mounting evidence and growing support within the cerebellar field indicate that it participates in a much broader set of behaviors outside of motor control, including attention, executive function, and behavioral flexibility. At an anatomical level, human, non-human primate, and rodent functional imaging and tract tracing methods point to a diverse set of likely cerebellar targets in the forebrain capable of supporting such behaviors (e.g. thalamus, basal ganglia, and prefrontal and parietal cortices). Furthermore, disruption of connectivity between the cerebellum and downstream forebrain regions is thought to result in a loss of specific aspects of motor and non-motor function. The paper I will present combines neuroimaging and nueormodulation in both human and animals models to examine the role of one specific region of the cerebellar cortex, CrusI, in ASD-related behaviors. This paper and my discussion should be of interest to a broad swath of the ICLM community especially those interested in ASD, animal behavior (e.g. social, persevative, and cognitive/behavioral flexibility), and techniques for defining functional connectivity in the brain.
Papers: https://www.nature.com/articles/s41593-017-0004-1
About Us
Introduction
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Organizers:
Shonali Dhingra & Helen Motanis
Current Faculty Advisor:
Past Organizers:
i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)
ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)
iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)
iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)
v) Walt Babiec (O'Dell Lab) (2013-2014)
vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)
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