ICLM Journal Club
This Week - 06 May 2022 (9:30 a.m., via Zoom)
Speaker: Ana Sias
Title: “ Dopamine projections to the basolateral amygdala mediate the encoding of outcome-specific reward memories. ”
Summary: To make adaptive decisions, we often use cues in our environment to retrieve detailed memories of associated rewards and choose accordingly. Emerging evidence suggests ventral tegmental area (VTA) dopamine might be involved in learning the relationship between a cue and the identifying features of the specific reward it predicts (i.e., model-based learning). But the projections through which dopamine does this are unknown. Using optical imaging and manipulation methods coupled with the outcome-specific Pavlovian-to-instrumental transfer task, we investigate the contribution of dopaminergic projections to the basolateral amygdala in forming these detailed associative reward memories.
Relevant Papers: https://elifesciences.org/articles/68617
The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;
1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.
2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.
3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.
History of ICLM
The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.
Current Faculty Advisor:
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