ICLM Journal Club

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This Friday - October 7, 2022 (9:30 a.m., in person, Gonda 1357)

Speaker: Letizia Ye

Title: Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

Summary: Striatal circuits play a crucial role in modulating motor output and cognition, yet whether these processes involve direct control of movement or reflect an underlying cognitive process has not been fully understood. Bolkan et al., demonstrate that the contribution of the direct and indirect dorsomedial striatum (DMS) pathways depends on cognitive demands of a task in mice. Utilizing latent state models, Bolkan et al., demonstrate that the direct and indirect dorsomedial striatum (DMS) pathways contribute to behavior in an opposing and state-dependent manner and reveal underlying decision-making strategies. In summary, opponent control of behavior by DMS pathways depends on both the demands imposed by a task and the internal state of mice when performing it.

Relevant Papers: Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state, Scott S. Bolkan, Iris R. Stone, Lucas Pinto, Zoe C. Ashwood, Jorge M. Iravedra Garcia, Alison L. Herman, Priyanka Singh, Akhil Bandi, Julia Cox, Christopher A. Zimmerman, Juonhong Ryan Cho, Ben Engelhard, Jonathan W.Pillow and Ilana B Witten, Nat Neurosci. (2022)

About Us


The Integrative Center for Learning and Memory (ICLM) is a multidisciplinary center of UCLA labs devoted to understanding the neural basis of learning and memory and its disorders. This will require a unified approach across different levels of analysis, including;

1. Elucidating the molecular cellular and systems mechanisms that allow neurons and synapses to undergo the long-term changes that ultimately correspond to 'neural memories'.

2. Understanding how functional dynamics and computations emerge from complex circuits of neurons, and how plasticity governs these processes.

3. Describing the neural systems in which different forms of learning and memory take place, and how these systems interact to ultimately generate behavior and cognition.

History of ICLM

The Integrative Center for Learning and Memory formally LMP started in its current form in 1998, and has served as a platform for many interactions and collaborations within UCLA. A key event organized by the group is the weekly ICLM Journal Club. For more than 10 years, graduate students, postdocs, principal investigators, and invited speakers have presented on topics ranging from the molecular mechanisms of synaptic plasticity, through computational models of learning, to behavior and cognition. Dean Buonomano oversees the ICLM journal club with help of student/post doctoral organizers. For other events organized by ICLM go to http://www.iclm.ucla.edu/Events.html.

Current Organizers:

Saray Soldado (Buonomano Lab) & Lukas Oesch (Churchland Lab). Please email us at iclm.journalclub@gmail.com if you would like to get regular updates regarding our journal club and weekly reminders.

Current Faculty Advisor:

Dean Buonomano

Past Organizers:

i) Anna Matynia(Aug 2004 - Jun 2008) (Silva Lab)

ii) Robert Brown (Aug 2008 - Jun 2009) (Balleine Lab)

iii) Balaji Jayaprakash (Aug 2008 - Nov 2011) (Silva Lab)

iv) Justin Shobe & Thomas Rogerson (Dec 2011 - June 2013) (Silva Lab)

v) Walt Babiec (O'Dell Lab) (2013-2014)

vi) Walt Babiec (O'Dell Lab) & Helen Motanis (Buonomano Lab) (2014-2017)

vii) Helen Motanis (Buonomano Lab) & Shonali Dhingra (Mehta Lab) (2017-2018)

viii) Shonali Dhingra (Mehta Lab) (2018-2020)

ix) Megha Sehgal (Silva Lab) & Giselle Fernandes (Silva Lab) (2020-2022)

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