Previous weeks
Contents
- 1 Summer 2010:
- 1.1 Cortical methylation maintains remote memory
- 1.2 Activity-dependent nuclear translocation from synapse to nucleus of the Transducer of Regulated CREB 1(TORC1)/CREB Regulated Transcriptional Co-activator 1 (CRTC1)
- 1.3 Metaplasticity at Single Synapses
- 1.4 The reorganization and reactivation of hippocampal maps predict spatial memory performance
- 2 Previous Semesters
Summer 2010:
Jun 25th
Cortical methylation maintains remote memory
Speaker: Justin Shobe
Summary of the talk:
Relevant Paper :
Jul 09th
Activity-dependent nuclear translocation from synapse to nucleus of the Transducer of Regulated CREB 1(TORC1)/CREB Regulated Transcriptional Co-activator 1 (CRTC1)
Speaker : Kelsey Martin
Summary of the talk :
Relevant Paper :
Jul 30th
Metaplasticity at Single Synapses
Speaker: Adam Frank
Summary of the talk: Neuronal activity is known to modify NMDA receptor subunit composition; and, NMDAR subunit composition has significant effects on NMDAR synaptic currents. Given the importance of the NMDAR in the induction of LTP it is not surprising that altering NMDAR currents, by altering subunit composition, has demonstrated effects on the induction of LTP. Lee et al. now demonstrate these phenomena at the level of single synapses in cultured hippocampal neurons: altering spontaneous activity changes the ratio of NR2B to NR2A subunits and effects both NMDAR synaptic current as well as LTP induction threshold. These findings are presented in the context of metaplasticity, where prior activity at a synapse effects the subsequent ability of the synapse to undergo plasticity.
Relevant Paper :
06th Aug
The reorganization and reactivation of hippocampal maps predict spatial memory performance
Speaker: Walt Babiec
Summary: The hippocampus has place cells that preferentially fire at a particular location of spatial arena. Dupret et al. report that place fields remapped as a result of goal-directed spatial learning and that sharp wave/ripple reactivation events seen during memory consolidation predicted the strength of subsequent spatial memory.
Relevant Paper :