Iclm:Current events
From LMP Journal Club
Date: Apr 27th
Time: 09:30 am
Place : 2nd Floor Conference Room, Gonda building.
Title :The role of Thorase in the surface expression of glutamate receptors and its implications for synaptic plasticity and behavior
Speaker: Adam Roberts
Summary: Zhang et al., 2011 indicate that the AAA+ ATPase Thorase is required for the internalization of AMPARs by dissociating the GRIP1-GluR2 interaction. Genetic manipulation of Thorase expression modifies the surface expression of GluR1 and GluR2 in an ATP-dependent manner. Thorase KO mice have enhanced LTP, deficits in LTD, and larger AMPAR-dependent currents. These alterations in nervous system function result in deficits in learning and memory.
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